

Brittany M. Hufft-Martinez, PhD
Brittany M. Hufft-Martinez, PhD
CSTI-TL1 Postdoctoral Fellow
Saadi Lab
The University of Kansas Medical Center
CSTI-TL1 Postdoctoral Fellow
Saadi Lab
The University of Kansas Medical Center
Hi! I'm Brittany.
Scientist.Wife.Friend.Creator.Animal Lover.
I am a Postdoctoral fellow in Dr. Irfan Saadi’s laboratory at the University of Kansas Medical Center (KUMC) in the Department of Cell Biology and Physiology. I am also a member of the Institute for Reproductive and Developmental Sciences (IRDS). My ultimate goal is to enter a career in translational research. My postdoctoral project investigates the mechanisms by which nutrient changes in the maternal environment rescue cleft palate (CP). This finding was serendipitously uncovered during my doctoral training, where I identified a genetic interaction between cytoskeletal SPECC1L and THM1 (funded NIH F31). During the first year of my postdocotral position, I received three fellowships (Biomedical Research Training Program-KUMC, K-INRE Postdocotral Fellowship- NIH, TL1 Postdoctroal Fellowship-NIH CTSA).
When I began graduate school, my idea of success included the goal of impacting one person with my work. I am happy to report that beyond my research endeavors, I was able to establish a partnership between KUMC and my undergraduate institution Rockhurst University (RU) to provide research experiences to RU undergraduates. The idea for this partnership blossomed out of the broader impacts section of my successfully funded National Science Foundation Graduate Research Fellowship (NSF GRFP), which I obtained as an undergraduate. To date 55 undergraduates have received research opportunities at the KUMC in a variety of subjects spanning Alzheimer’s Disease, birth defects, obesity, cancer, Polycystic Kidney Disease, autophagy, DNA repair, COVID, ovarian aging, ciliogenesis, and O-GlcNAc biology.
Due to this work I received two awards as a gradaute student, 2023 Dorothy Knoll Outstanding Student Leadership Award (KUMC) and 2023 Student Achiever STEMMy award (Central Exchange). Beyond my research and outreach, I have learned to teach cadaver anatomy and am now an instructor for first- and second-year medical students at the University of Kansas Medical Center.
"Science: If you don't make mistakes, you're doing it wrong. If you don't correct those mistakes you're doing it really wrong. If you can't accept that you're mistaken, you're not doing it at all." -Anon
Upcoming Events
Well-Being Conference KUMC
Managing Personal Well-Being Panel
May 21, 2025
ASTRA Collective + KC RIBS
Childrens Mercy Research Institute
June 5, 2025
Innovation Festival- BioKansas
August 12, 2025
"Play is the highest form of research"
Albert Einstein
Publications
Research Articles and Chapters
“The most beautiful thing in the world is, precisely, the conjunction of learning and inspiration. Oh, the passion for research and the joy of discovery!” - Wanda Landowaska
Partially redundant actin genes in Chlamydomonas control transition zone and flagellum-directed protein dynamics.
Jack B, Mueller DM, Fee AC, Tetlow A, Avasthi P. Partially redundant actin genes in Chlamydomonas control transition zone and flagellum-directed protein dynamics. Cell Reports. 2019 May 21. DOI: https://doi.org/10.1016/j.celrep.2019.04.087
Chemical Screening for Flagella-Associated Phenotypes in Chlamydomonas reinhardtii
Jack, Brittany & Avasthi, Prachee. (2018). Chemical Screening for Flagella-Associated Phenotypes in Chlamydomonas reinhardtii. Methods in molecular biology (Clifton, N.J.). 1795. 203-221. 10.1007/978-1-4939-7874-8_17.
Intraflagellar Transport Proteins as Regulators of Primary Cilia Length
Wang W, Jack BM, Wang HH, Kavanaugh MA, Maser RL, Tran PV. Intraflagellar Transport Proteins as Regulators of Primary Cilia Length. Front Cell Dev Biol. 2021 May 19;9:661350. doi: 10.3389/fcell.2021.661350. PMID: 34095126; PMCID: PMC8170031.
In-frame deletion of SPECC1L microtubule association domain results in gain-of-function phenotypes affecting embryonic tissue movement and fusion events
Goering, JP, Wenger, LW, Stetsiv, M, Moedritzer, M, Hall, EG, Isai, DG, Jack, B, Umar, Z, Rickabaugh, M, Czirok, A, Saadi, I. (2021) In-frame deletion of SPECC1L microtubule association domain results in gain-of-function phenotypes affecting embryonic tissue movement and fusion events. Human Molecular Genetics (In Press)
Thm2 interacts with paralog, Thm1, and sensitizes to Hedgehog sigaling in postnatal skeletogenesis
Allard BA, Wang W, Pottorf TS, Mumtaz H, Jack BM, Wang HH, Silva LM, Jacobs DT, Wang J, Bumann EE, Tran PV. Thm2 interacts with paralog, Thm1, and sensitizes to Hedgehog signaling in postnatal skeletogenesis. Cell Mol Life Sci. 2021 Apr;78(7):3743-3762. doi: 10.1007/s00018-021-03806-w. Epub 2021 Mar 8. PMID: 33683377.
Actin cytoskeletal regualtion of ciliogenesis in development and disease
Hufft-Martinez, B. M., H. H. Wang, I. Saadi, and P. V. Tran. 2024. 'Actin cytoskeletal regulation of ciliogenesis in development and disease', Dev Dyn, 253: 1076-93.
Novel insights into palatal shlef elevation dynamics in normal mouse embryos
Goering, J. P., M. Moedritzer, M. Stetsiv, D. G. Isai, B. M. Hufft-Martinez, A. J. Tran, Z. Umar, M. K. Rickabaugh, P. Keselman, M. Chauhan, P. V. Tran, W. M. Brooks, K. J. Fischer, A. Czirok, and I. Saadi. 2025. 'Novel insights into palatal shelf elevation dynamics in normal mouse embryos', Front Cell Dev Biol, 13: 1532448.
Copyright 2018